Principal Investigator

Assistant Professor, School of Pharmacy, Sungkyunkwan University, Suwon, Korea

Assistance Professor, Pusan National University Medical School, Gyeongsangbukdo, Korea

Jun, S.H.*,**, Hyun, J.*, Cha, J.S., Kim, H., Barlett, M.S., Cho, H.S.** and Murakami, K.S.** (2020) Direct binding of TFEα opens DNA binding cleft of RNA polymerase. Nature communications. 11: 6123

Lee, H.J.*, Jeong, H.*, Hyun, J.*, Ryu, B., Park, K., Lim, H.H., Yoo, J. and Woo, J.S.** (2020) Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel. Science Advances. 6(35), eaba4996

Kim, K., Jung, J.H, Yoo, H.J., Hyun, J., Park, J.H., Na, D. and Yeon, J.H.** (2020) Anti-metastatic effects of plant sap-derived extracellular vesicles in a 3D microfluidic cancer metastasis model. Journal of Functional Biomaterials. 11(3): 49

Kim, G.*, Lee, S.G.*, Han, S., Jung, J., Jeong, H.S., Hyun, J., Rhee, D.K., Kim, H.M.** and Lee, S.** (2020) ClpL is a functionally active tetradecameric AAA plus chaperone, distinct from hexameric/dodecameric ones. FASEB Journal. In press

Kim, K.*, Yoo, H.J., Jung, J.H., Lee, R., Hyun, J.K., Park, J.H., Na, D. and Yeon, J.H.** (2020) Cytotoxic Effects of Plant Sap-Derived Extracellular Vesicles on Various Tumor Cell Types. Journal of Functional Biomaterials. 11(2), 22

Ahn, J.*, Lee, D., Jo, I., Jeong, H., Hyun, J., Woo, J.S., Choi, S.H. and Ha, N.C.** (2019) Real-Time Measurement of the Liquid Amount in Cryo-Electron Microscopy Grids Using Laser Diffraction of Regular 2-D Holes of the Grids. Molecules and Cells. 43(3), 298-303

Desfosses, A.*, Venugopal, H., Joshi, T., Felix, J., Jessop, M., Jeong, H., Hyun, J., Heymann, J. B., Hurst, M.R., Gutsche, I.** and Mitra, A.K.** (2019) Atomic structures of an entire contractile injection system in both the extended and contracted states. Nature Microbiology. 4(11), 1885-1894

Lee, Y.*, Kim, B.S., Choi, S., Lee, E.Y., Park, S., Hwang, J., Kwon, Y., Hyun, J., Lee, C., Kim, J.F., Eom, S.H. and Kim, M.H.** (2019) Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity. PNAS. 116(36), 18031-18040

Jo, I.*, Kim, J.S., Xu, Y., Hyun, J., Lee, K. and Ha, N.C.** (2019) Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system. Journal of Microbiology. 57(3), 185-194

 

Kwon, D.H.*, Park, O.H., Kim, L., Jung, Y.O., Park, Y., Jeong, H., Hyun, J., Kim, Y.K. and Song, H.K.** (2018) Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter. Nature Communications. 9, 3291  

Jeong, H.*, Yoo, S.J., Won, J., Lee, H.J., Chung, J.M., Kim, H., Kim, G.J., Kim, J.G., Jung, H.S., Hyun, J.** (2018) Analysis of nano-crystals: Evaluation of heavy metal-embedded biological specimen by high voltage electron microscopy. Ultramicroscopy. 194, 35-39

Castaneda, N.*, Zheng, T., Rivera-Jacquez, H.J., Lee, H.J., Hyun, J., Balaeff, A., Huo, Q. and Kang, H.** (2018) Cations Modulate Actin Bundle Mechanics, Assembly Dynamics, and Structure. Journal of Physical Chemistry B. 122(14) 3826-3835

Jo, I.*, Hong, S., Lee, M., Song, S., Kim, J.S., Mitra, A.K., Hyun, J., Lee, K. and Ha, N.C.** (2017) Stoichiometry and mechanistic implications of the MacAB-TolC tripartite efflux pump. Biochemical and Biophysical Research Communications.494, 668-673

Mitra, A.K.**, Desfosses, A., Venugopal, H., Joshi, T., Hyun, J.K., Bhardwaj, P., and Hurst, M.** (2017) Revealing the atomic-level organization of a bacterial microinjection nanodevice. Acta Crystallographica Section A. A73, C1325

Jaballah, S.A., Bailey, G.D., Desfosses, A., Hyun, J.K., Mitra, A.K. and Kingston, R.L.** (2017) In vitro assembly of the Rous Sarcoma Virus capsid protein into hexamer tubes under physiological conditions. Scientific Reports. 7, 2913

Ahn, M.*, Gunasekaran, P., Rajasekaran, G., Kim, E.Y., Lee, S.-J., Bang, G., Cho, K., Hyun, J.K., Lee, H.-J., Jeon, Y.H., Kim, N.-H., Ryu, E.K., Shin, S.Y.** and Bang, J.K.** (2017) Pyrazole derived ultra-short antimicrobial pepridomimetics with potenet anti-biofilm activity. European Journal of Medicinal Chemistry. 125, 551 – 564

Jeong, H.*, Kim, J.-S.*, Song, S., Shigematsu, H., Yokoyama, T., Hyun, J.K.** and Ha, N.-C.** (2016) Pseudoatomic structure of the tripartite multidrug efflux pump AcrAB-TolC reveals the intermeshing cogwheel-like interaction between AcrA and TolC. Structure. 24, 272-276

Song, C.*, Lee, J.H., Jun, S., Chung, J.M., Hyun, J., and Jung, H.S.** (2016) Technical advances in intracellular detection using immune-gold particles: Simple cryofixation with metal contact quick freezing. Journal of Nanoscience and Nanotechnology. 16(5), 4593-4597

Jeong, J.A.*, Hyun, J. and Oh, J.I.** (2015) Regulation Mechanism of the ald Gene Encoding Alanine Dehydrogenase in Mycobacterium smegmatis and Mycobacterium tuberculosis by the Lrp/AsnC Family Regulator AldR. Journal of Bacteriology. 197(19), 3142-3153

Kim, J.-S.*, Jeong, H.*, Song, S., Kim, H.-Y., Lee K., Hyun, J.K.** and Ha, N.-C.** (2015) Structure of the tripartite multidrug efflux pump AcrAB-TolC suggests an alternative assembly mode. Molecules and Cells. 38(2), 180-186

Kang, B.*, Eom, C.-Y., Kim, W., Kim, P.I., Ju, S.Y., Ryu, J., Han, G.H., Oh, J.-I., Cho, H., Baek, S.H., Kim, G., Kim, M., Hyun, J.K., Jin, E.S. and Kim, S.W.** (2015) Construction of target-specific virus-like particles for the delivery of algicidal compounds to harmful algae. Environmental Microbiology . 17(4), 1463-1474

Gwak, Y.*, Jung, W., Lee, Y., Kim, J.S., Kim, C.G., Ju, J.H., Song, C., Hyun, J.K.** and Jin, E.S.** (2014) An intracellular antifreeze protein from Antarctic microalga that responds to various environmental stresses. The FASEB Journal. 28, 4924-4935

Ahn, M.*, Jacob B., Gunasekaran, P., Murugan, R.N., Ryu, E.K., Lee, G., Hyun, J.K., Cheong, C, Kim, N.H., Shin, S.Y. and Bang, J.K.** (2014) Poly-lysine peptidomimetics having potent antimicrobial activity without hemolytic activity. Amino Acids. 46, 2259-2269

Ahn, M.*, Rajasekaran G., Gunasekaran, P., Ryu, E.K., Lee, G., Hyun, J.K., Cheong, C, Kim, N.H., Shin, S.Y. and Bang, J.K.** (2014) Enhancement of antibacterial activity of short Tryptophan-rich antimicrobial peptide Pac-525 by replacing Trp with His(chx). Bulletin of the Korean Chemistry Society. 35(9), 2818-2824

Lim, H.*, Cheong, H.K., Rho, J.R., Hyun, J.K.** and Kim, Y.J.** (2014) Expression, purification and characterization of human vacuolar-type H+-ATPase subunit d1 and d2 in Escherichia coli. Protein Expression and Purification. 98, 25-31

Jacob, B.*, Kim, Y., Hyun, J.K., Park, I.S., Bang, J.K., Shin, S.Y.** (2014) Bacteria killing mechanism of sheep myeloid antimicrobial peptide-18(SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity. Amino Acids. 46(1), 187-198

Kim, M.*, Kim, S.Y., Lee, H.W., Shin, J.S., Kim, P., Jung, Y.S., Jeong, H.S., Hyun, J.K., Lee, C.K.** (2013) Inhibition of influenza virus internalization by (-)-epigallocatechin-3-gallate. Antiviral Research. 100, 460-472

Murugan, R.N.*, Jacob, B., Ahn, M., Hwang, E., Sohn, H., Park, H.N., Lee, E., Seo, J.H., Cheong, C., Nam, K.Y., Hyun, J.K., Jeong, K.W., Kim, Y., Shin, S.Y., Bang, J.K.** (2013) De novo design and synthesis of ultra-short peptidomimetic antibiotics having dual antimicrobial and anti-inflammatory activities. PLoS One. 8, e80025

Kwon, K.*, Choi, D., Hyun, J.K., Jung, H.S., Baek, K., Park, C.** (2013) Novel glyoxalases from Arabidopsis thaliana based on sequence similarities and molecular modeling.  FEBS Journal. 280(14), 3328-3339

Ahn, M.*, Murugan, R.N.*, Jacob, B.*, Hyun, J.K.*, Cheong, C., Hwang, E., Park, H.N., Seo, J.H., Lee, K.S., Shin, S.Y. and Bang, J.K.** (2013) Discovery of novel histidine-derived lipo-amino acids: Applied in the synthesis of ultra-short antimicrobial activity, salt resistance and protease stability. European Journal of Medicinal Chemistry. 68, 10 – 18

Murugan, R.N.*, Jacob, B., Kim, E.H., Ahn, M., Sohn, H., Seo, J.H., Cheong, C., Hyun, J.K., Lee, K.S., Shin, S.Y. and Bang, J.K.** (2013) Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents. Bioorganic and Medicinal Chemistry Letters. 23, 4633 – 4636

Lee, J.W.*, Lee, S., Jang S., Han, K.Y., Kim Y., Hyun, J.K., Kim S.K. and Lee, Y.** (2013) Preparation of non-aggregated fluorescent nanodiamonds (FNDs) by non-covalent coating with a block copoloymer and proteins for enhancement of intracelluar uptake. Molecular Biosystems. 9 (5), 1004 – 1011

Chae, H.B.*, Moon, J.C., Shin, M.R., Yoo, J.Y., Chi, Y.H., Jung, Y.J., Lee, S.Y., Nawkar, G.M., Jung, H.S., Hyun, J.K., Kim, W.Y., Kang, C.H., Yun, D.J., Lee, K.O. and Lee, S.Y.** (2012) Thioredoxin reductase type C (NTRC) orchestrates enhanced thermotolerance to Arabidopsis by its redox-dependent holdase chaperone function. Molecular Plant. 6 (2), 323 – 336

Bailey, G.B.*, Hyun, J.K., Mitra, A.K. and Kingston, R.L.** (2012) A structural model for the generation of continuous curvature on the surface of a retroviral capsid. Journal of Molecular Biology. 417 (3), 212 – 223

Hyun, J.K.*, Accurso, C.*, Hijnen, M., Schult, P., Pettikiriarachchi, A., Mitra, A.K.** and Coulibaly, F.** (2011) Membrane remodeling by the double-barrel scaffolding protein of poxvirus. PLoS Pathogens. 7 (9), e1002239

Radjainia, M.*, Hyun, J.K., Leysath, C.E., Leppla, S.H. and Mitra A.K.** (2010) An anthrax toxin neutralizing antibody reconfigures the protective antigen heptamers into a super complex. Proceedings of the National Academy of Sciences. 107 (32), 14070 – 14074

Hyun, J.K.*, Radjainia, M., Kingston, R.L. and Mitra, A.K.** (2010) Proton-driven assembly of the Rous sarcoma virus capsid protein results in formation of icosahedral particles. Journal of Biological Chemistry. 285 (20), 15056 - 64

Bailey, G.B.*, Hyun, J.K., Mitra, A.K.** & Kingston, R.L.** (2009) Proton-linked dimerisation of a retroviral capsid protein initiates capsid assembly. Structure. 17 (5), 737-748.

Hyun, J.K.*, Coulibaly, F., Turner A.P., Baker E.N. and Mitra A.K.** (2007) The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses. Journal of Virology. 81 (20), 11075 – 11083.